PHOTO: The harbourside residence is set on 1100 square metres on which a pool was added after it last sold in 1998.

The landmark Spanish Mission residence Villa Biscaya in Rose Bay has sold, ending a more than five-year sales campaign that started in 2014.

Medical entrepreneur Robert Gregg and his wife Elaine have long maintained throughout one of the country’s most bullish property booms a $12.5 million guide for the historic house, although it remains unknown if they will pocket as much when it settles.

Despite the sale price being undisclosed, records show it was bought by recently separated Janette and David Waterhouse, the latter of whom is the former art collector, options trader and a long estranged member of the prominent horse racing family.

Jaime Upton, of Sotheby’s International, is yet to respond to calls, but the listing has been removed from online property portal and the Waterhouses have lodged their interest on title records.

Villa Biscaya 6 Tivoli Avenue Rose Bay
The two-storey house overlooking Sydney Harbour was restored in 1999 and in 2001 won a Woollahra Conservation Award.